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If your gut lining becomes leaky, toxins from bacteria can enter your bloodstream, triggering inflammation that makes it even harder for insulin and GLP-1 to do their jobs

The researchers optimized the potency ratio between the three receptors and used a protraction strategy that allows for once-weekly dosing, then tested the drugs in diet-induced obese mice

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At the heart of their effectiveness is GLP-1, a hormone that plays a crucial role in controlling appetite and metabolism